Munchkin
Steve Jackson Games
Munchkin is a competitive game from Steve Jackson (co-founder of Games Workshop). Its a classic parody of the D&D game, without the complexity! with a cards like the “duck of doom” and the motto “Time To kill the monsters, Steal the treasure and stab your buddy.”
Bonus: Watch Will Wheaton from geek and sundry's table top play Munchkin
Star Fluxx
Eagle Games
Star Fluxx is an amazing game where the rules of the game are defined by the game as you play. Easy to get started and a lot of fun. This particular version offers an amusing parody of the sci-fi world.
Bonus: Watch Will Wheaton from geek and sundry's table top play Star Fluxx